Comparing Zinc Sources: Study Shows Organic Zinc More Readily Absorbed in Calves

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Zinc is an essential mineral in dairy nutrition, playing a key role in growth, immune health, and reproductive performance. But not all zinc supplements are created equal. A recent study published in the Journal of Dairy Science sheds new light on how well different forms of zinc are absorbed by young calves — and it may help dairy producers make more informed choices when formulating rations.

What the Study Looked At:
Researchers compared two common zinc sources:

  • Zinc sulfate (Zn-SO) – an inorganic form.

  • Zinc methionine hydroxy analog chelate (Zn-MHAC) – an organic form.

To measure how much of each was actually absorbed, the team used stable isotopes — safe, non-radioactive markers that track zinc inside the body.

Eighteen young Holstein calves were given a single dose (0, 4, or 8 mg) of either zinc source. Over the next 72 hours, researchers measured how much zinc showed up in the blood and various tissues (like liver, skin, lungs, hoof, and bone).

Key Findings:

  • Higher absorption from organic zinc: Calves given Zn-MHAC (organic) had significantly more zinc in nearly all tissues tested compared to those given Zn-SO (inorganic).

  • Dose mattered: The 8 mg dose led to greater zinc uptake than 4 mg or 0 mg, regardless of the source.

  • The liver was the only organ where weight changed based on dose (heavier with 4 mg), but this was not tied to the source type.

  • Blood zinc measurements didn’t differ by source, showing the importance of tissue testing to detect long-term zinc uptake.

Why This Matters:
While blood tests are easy to collect, they may not tell the full story when it comes to zinc absorption. This study confirms that tissue zinc levels — and therefore potential health benefits — are more affected by the form of zinc used.

Takeaway for Dairy Producers:

  • Organic zinc sources like Zn-MHAC may be more bioavailable, meaning the calf’s body can absorb and use them more effectively.

  • Using stable isotopes offers a reliable way to measure mineral absorption without radiation risk.

  • Choosing the right form and dose of zinc can support better health outcomes in youngstock.


Quick Summary for Decision-Makers:

  • Organic zinc (Zn-MHAC) = better absorption

  • Higher zinc dose = greater uptake

  • Blood zinc alone may not reflect true absorption

  • Stable isotope tracking = accurate, non-invasive method

This research supports considering organic trace minerals in calf diets, especially when aiming for optimal growth and immune function.